GDNF protein Parkinson’s treatment ‘extremely promising’

Science & Medical

A trial has found that an experimental drug called GDNF could offer hope for restoring damaged brain cells in Parkinson’s patients. Scientists said some brain scans revealed “extremely promising” effects on damaged neurons after the protein therapy was delivered directly into the brains of Parkinson’s patients.

Glial Cell Line Derived Neurotrophic Factor (GDNF) is a protein that, in humans, is encoded by the GDNF gene. In experiments on mice it has been found to be an important physiological regulator of the functioning of the brain’s dopamine neurons, which play an important role in cognitive control, learning and motor control.

The experimental treatment is made by Canadian biotech firm MedGenesis Therapeutix.

“The spatial and relative magnitude of the improvement in the brain scans is beyond anything seen previously in trials,” said Alan Whone, a Parkinson’s specialist at Britain’s Bristol University who co-led the trial.

After nine months, there was no change in the scans of patients who received a placebo, but those receiving GDNF showed major changes in a key area of the brain affected by the disease.

Whone said this suggested GDNF could be “a means to possibly reawaken and restore” brain cells that are gradually destroyed in Parkinson’s. The drug “engages with its target, dopamine nerve endings, and appears to help damaged cells regenerate or have a biological response.”

Patients in the trial had, on average, been diagnosed eight years previously, but brain scans of those given the drug showed images that would be expected just two years after diagnosis.

Participant Tom Phipps, 63, from Bristol, said: “My outcome was as positive as I could have wished for. I feel the trial brought me some time and has delayed the progress of my condition.”

A scientific study in 2018, “Psychedelics Promote Structural and Functional Neural Plasticity”, showed how the use of psychedelics like ibogaine and ketamine, as well as others like LSD and DMT, stimulate the GDNF gene, increasing spinal cord growth and nerve synapses.

This new protein treatment may be a breakthrough but it is clear that states have long blocked the use of other drugs with the potential to treat Dementia, Alzheimers, Parkinson’s and other neurological conditions, locking up people brave enough to make such compounds available.

The US Government have held a patent on cannabis capable of being used for neuroprotection against these disorders since 1972. Meanwhile they have waged the ‘War on Drugs’ and forced other nations across the world to follow suit. They have known the harm they have caused and carried on into a situation where we have just had to endure the blind leading the blind for longer than Moses walked the desert.

Cannabis is also linked to neurogenesis, much like the natural psychedelics psilocybin and DMT. For decades we have been told these drugs will quite literally rot your brain. All along it’s been known that it builds extensions to the neural pathways in your brain. Imagine building a conservatory in your brain where you think in more expansive and clearer ways.

For the sake of our loved ones, the drug stigma has to end. The dogma is that drugs are bad for the brain. The likelihood is that these naturally occurring plants, which have drugs (medicines) in them, specifically target age-related neurological disorders that have been on the rise since they were outlawed – they might just be the answer!

3 thoughts on “GDNF protein Parkinson’s treatment ‘extremely promising’

  1. I am a 51 year old female that just found out I have Motor Neuron Disease Parkinson’s about a year and half, but I have been having signs of it for years, tremors, depression, body weakness. ECT. I honestly don’t think my doctor was reading the signs because of my gender and age. A few years ago I had my shoulder lock up on me and I was sent to a P.T since x-rays didn’t show any physical damage. My shaking was getting worse and I began falling. Only when my speech became so bad that it brought concern to my dentist was Parkinson’s even considered. He phoned my doctor with his concerns about my shaking and balance problems. By this time I was forgoing shots in the back of my neck for back and neck pain to which once again I was sent to a P.T (although x-rays showed no damage) I was told I had a few spurs which were most likely causing the pain. Here I was feeling like my whole body was falling apart and doctor could not find anything wrong, maybe in was all in my head? My doctor even seemed annoyed with me and things just kept progressing and I just kept it to myself, why bother going through testing and them finding nothing? Well, it was after my second P.T called my doctor about the weakness in my legs and arms, by this time I have developed a gait in my walk and I fell more frequently. Only then did my doctor send me to a specialist and it was found that I had Parkinson’s, and that I have had it for awhile. I think because I was a woman that my signs and symptoms weren’t taken seriously and therefor left untreated for so long,I was taking pramipexole dihydrochloride three times daily, I Was on carbidopa levodopa but only lasted 90 minutes then wore off.I found that none of the current medications worked effective for me.I got tired of using those medication so I decided to apply natural herbs formula that was prescribed to me by my second P.T, i purchase the herbal formula, There has been huge progression ever since I start the treatment plan which will last for 15 weeks usage.all the symptoms and sign has begin to disappear .

  2. I was diagnosed with Parkinson’s disease nearly 4 years ago, at age 51. I had a stooped posture, tremors, muscle stiffness, sleeplessness, and slow movement. I was placed on Sinemet for 7 months and then Sifrol and rotigotine were introduced which replaced the Sinemet but I had to stop due to side effects. I was in denial for a while as there is no history of PD in my family. I also used amantadine, and physical therapy to strengthen muscles all failed. I decided to adopt a more natural approach and started on Parkinson’s Herbal formula from Organic Herbal Clinic, the Parkinson’s natural formula immensely helped my condition, i had a total recovery from PD with this natural herbal formula treatment. Organic Herbal Clinic official web site www . organicherbalclinic . com. I feel alive again!!

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